A mistake is a when someone does something that they did not intend to do. Usually this is a result of ignorance or misunderstanding. I currently think that all humans make mistakes. For the most part, it is poor communication which causes misunderstanding.
I make mistakes constantly in my writing and speaking. My mistakes are relevant because I can learn from them. I will admit that I wish that I did not make any mistakes, but since it is currently a fact of my life, I continue on and try to correct my mistakes.
Another reason that mistakes are relevant to me personally is because I know that my own existence is a mistake. What I mean is, if the world had always been perfect, I would never have been born. My parents would never have met. I know enough of the history to see why the whole marriage was based on lies, ignorance, and miscommunication.
This does not mean that somehow I am more flawed than anyone else. Just because someone is a descendant of someone who did many irrelevant things does not mean that they cannot find their own relevance and learn new information which can help them avoid the mistakes of their ancestors.